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Dementia occurs more commonly in Parkinson’s disease (PD) than in the age-matched general population and estimated prevalence are about 40%, but the prevalence are much variable depending on the study population, method and the definition of dementia that is adopted. The pathogenesis of the cognitive impairment in PD is unclear, but the deficiency of several neurotransmitters, cortical Lewy bodies deposition, coexisting. Alzheimer’s disease pathology, vascular lesions and age-related changes are considered. The cognitive changes most often associated with PD are executive, mnemonic and visuospatial impairment, which are different with those of Alzheimer’s disease. PD dementia don’t respond to dopaminergic treatment but cholinesterase inhibitors show initial encouraging results.
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